Monthly Archives: March 2018

TRIUMPH: Triple Low-Dose Combo Pill a Success in Hypertension !!!

MEDSCAPE >HEALTH NEWS Sue Hughes March 13, 2018   ORLANDO — A pill combining low doses of three antihypertensive medications decreased blood pressure faster and more effectively and increased the number of patients reaching goal compared with usual care, without increasing adverse effects, in a new study. The TRIUMPH trial was presented here at the American College… Read more »

Skipping Breakfast Linked to Increased Atherosclerosis

NEWS > MEDSCAPE MEDICAL NEWS Liam Davenport October 05, 2017   MADRID, SPAIN — Going without breakfast in the morning is associated with a substantially increased risk of developing subclinical atherosclerosis, a new observational study shows[1]. The findings provide support for previous reports suggesting dietary patterns can affect rates of cardiovascular events, the researchers say. In an… Read more »

Monoclonal Antibodies for Emerging Infectious Diseases — Borrowing from History

Panel A shows early techniques to collect polyclonal serum from individuals recovering from disease after infectious virus is cleared and antibody response has been generated. Panel B shows monoclonal antibody isolation from mice, using antigen introduction into mice, collection of B cells from mouse spleens, and production of fully mouse, antigen-specific monoclonal antibodies. Panel C shows a technique for isolation of monoclonal antibodies from humans, using antigen introduction (through natural infection or immunization), collection of immune cells from peripheral blood or lymphoid tissue, selection of B cells expressing antibodies of interest (e.g., using flow cytometry), and production of fully human, antigen-specific monoclonal antibodies. Panel D shows polyclonal antibodies binding diverse regions or epitopes on the virion, whereas Panel E shows monoclonal antibodies representing a single antibody that targets a single epitope.

Quadrupling Inhaled Glucocorticoid Dose to Abort Asthma Exacerbations

The NEW ENGLAND JOURNAL of MEDICINE Tricia McKeever, Ph.D., Kevin Mortimer, Ph.D., Andrew Wilson, M.D., Samantha Walker, Ph.D., Christopher Brightling, Ph.D., Andrew Skeggs, B.Sc., Ian Pavord, F.Med.Sci., David Price, F.R.C.G.P., Lelia Duley, M.D., Mike Thomas, Ph.D., Lucy Bradshaw, M.Sc., Bernard Higgins, Ph.D., Rebecca Haydock, B.Sc., Eleanor Mitchell, B.A., Graham Devereux, Ph.D., and Timothy Harrison,… Read more »